Images of Pikachu and other characters from the original Pokémon video games activate a particular and unique region in the visual cortex, according to research from University of Pennsylvania and Stanford University.

The study, which incorporated 11 Pokémon experts and 11 novices, sheds light on the brain’s organizational structure.

“Pokémon nowadays does not look like the original Game Boy graphics, so this was a trip down memory lane, and it yielded some interesting results,” said Penn doctoral student Michael Barnett, one of the study’s co-authors. “Our message isn’t that video games change your brain. Everything changes your brain.”